Revolutionizing Cardiac Regeneration: A Breakthrough in Cardiovascular Medicine

Revolutionizing Cardiac Regeneration: A Breakthrough in Cardiovascular Medicine

At Taros Discovery, we are proud to contribute to a groundbreaking innovation in cardiac regeneration! Our collaborative research has led to the discovery of ZXR-081, a first-in-class small molecule therapy that could redefine post-myocardial infarction treatment. Unlike conventional therapies that merely manage symptoms, ZXR-081 actively repairs the heart by inhibiting TOB1, a novel target originally identified in zebrafish and successfully translated into mammalian cardiac regeneration.

From Hit Identification to Lead Candidate Nomination

• A novel first-in-class cardiovascular project with the potential to regenerate damaged tissues and organs
• ZXR-081 replicates the natural regenerative power of zebrafish, demonstrating efficacy in non-regenerative mammals such as rodents
• Unlike current treatments, ZXR-081 actively repairs the heart, offering a transformative approach in cardiovascular medicine

Taros Discovery’s Scientific Contribution

• Cutting-edge Structure-Based Medicinal Chemistry Design
• Virtual screening of 5,000 molecules from Taros’ internal library led to promising hit
• Hits covered 12 different chemical scaffolds, ensuring structural diversity
• The analysis confirmed the predicted activity, guiding strategic hit-to-lead optimization
• Efficient synthesis of novel analogues through the DMTA cycle, leading to the rapid identification of ZXR-081 in under 100 molecules