Antimicrobial resistance: LsrK kinase inhibitors as Quorum Sensing modulators
Silvia Stotani, Mohan Padmanaban, Anna Karawajczyk, Dimitrios Tzalis
Taros
Abstract:
Antimicrobial resistance is posing a continuously-rising threat to global health. Each year in the EU, multidrug-resistant bacterial infections cause the death of ca. 25.000 patients, with further healthcare costs and productivity losses estimated to be at least EUR 1.5 billion. As shown in the picture, the estimated deaths attributed to antimicrobial resistance every year by 2050 will be over 10 million1.
Therefore, there is an urgent need for a better antibiotic stewardship and for the discovery and development of new drugs to fight against Gram-negative bacteria. The INTEGRATE project has assembled a team of 10 beneficiaries from eight EU member states, encompassing both academic and non-academic sectors, to form a consortium committed to train Early Stage Researchers (ESRs) in the discovery and preclinical validation of novel Gram-negative antibacterial agents and antibacterial targets.
Want to know more about this publication? Contact our scientists
Drug Discovery
Taros’ international and multidisciplinary team has more than 180 years of pharmaceutical R&D experience. Collectively as a team, we worked on more than 120 biomolecular…
custom chemical services
Custom Synthesis
We support our customers by providing first kg quantities of fine and specialty chemicals, cost reduction of existing syntheses, streamlining chemical processes considering…
