Indications and Gene Families

Our lead scientists worked on more than 120 biomolecular targets from all major gene families and across all main therapeutic areas to guide the way through drug discovery. We provide drug discovery expertise on G-protein coupled receptors (GPCR), nuclear (hormone) receptors, enzymes (such as kinases and proteases) and transporters, ion channels, as well as protein-protein interactions (PPI) and targeting RNA as a drug target. Our multidisciplinary team explores entry points into Medicinal Chemistry projects in an unbiased manner, from large high-throughput screening (HTS) campaigns and focused screening, to rational molecular design approaches, over chemogenomics and fragment-based screening as well as starting points from literature including published intellectual property (IP) matter. Tacit knowledge and disease area experience across indications and gene families enable our team to prioritize and select the most suitable drug discovery approach for successful and rapid identification of lead series and clinical candidate molecules.